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Insitute of Mathematical Science

Applied Mathematical Seminar77:A Deep Autoregressive Model for Phylogenetic Inference

Time: Thursday, June 20th, 2024 , 10:00-11:00

Location:IMS, RS408

Speaker: Cheng Zhang, Peking University 

Abstract:Designing flexible probabilistic models over tree topologies is important for developing efficient phylogenetic inference methods. To do that, previous works often leverage the similarity of tree topologies via hand-engineered heuristic features which would require domain expertise and may suffer from limited approximation capability. In this work, we propose a deep autoregressive model for phylogenetic inference based on graph neural networks (GNNs), called ARTree. By decomposing a tree topology into a sequence of leaf node addition operations and modeling the involved conditional distributions based on learnable topological features via GNNs, ARTree can provide a rich family of distributions over tree topologies that have simple sampling algorithms, without using heuristic features. We demonstrate the effectiveness and efficiency of our method on a benchmark of challenging real data tree topology density estimation and variational Bayesian phylogenetic inference problems.


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邮编:201210
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